Sirtuin 1 Retards Hyperphosphatemia-Induced Calcification of Vascular Smooth Muscle Cells
نویسندگان
چکیده
منابع مشابه
Sirtuin 1 retards hyperphosphatemia-induced calcification of vascular smooth muscle cells.
OBJECTIVE Arterial calcification is associated with cardiovascular disease as a complication of advanced atherosclerosis. Aged vascular cells manifest some morphological features of a senescent phenotype. Recent studies have demonstrated that mammalian sirtuin 1 (SIRT1), a histone deacetylase, is an exciting target for cardiovascular disease management. Here, we investigated the role of SIRT1 i...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2011
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.110.216739